Randal J Kaufman Selected Research

Familial Multiple Coagulation Factor Deficiency I

9/2011	Mice deficient in LMAN1 exhibit FV and FVIII deficiencies and liver accumulation of α1-antitrypsin.
6/2008	Genotype-phenotype correlation in combined deficiency of factor V and factor VIII.
6/2003	Bleeding due to disruption of a cargo-specific ER-to-Golgi transport complex.

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Randal J Kaufman Research Topics

Disease

14	Neoplasms (Cancer) 01/2020 - 10/2006
10	Inflammation (Inflammations) 10/2020 - 07/2008
9	Hemophilia A (Haemophilia) 07/2022 - 11/2002
8	Type 2 Diabetes Mellitus (MODY) 01/2021 - 07/2005
8	Fatty Liver 01/2021 - 04/2011
7	Starvation 03/2016 - 01/2002
7	Infections 04/2014 - 04/2003
6	Obesity 01/2020 - 04/2011
4	Insulin Resistance 01/2021 - 10/2008
4	Hemorrhage 01/2020 - 06/2003
4	Glucose Intolerance 11/2019 - 07/2005
4	Atherosclerosis 05/2015 - 08/2003
4	Virus Diseases (Viral Diseases) 04/2011 - 12/2003
3	Squamous Cell Carcinoma of Head and Neck 05/2019 - 01/2015
3	Hyperglycemia 01/2019 - 07/2005
3	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2017 - 12/2007
3	Colitis 04/2014 - 09/2012
3	Inborn Genetic Diseases (Disease, Hereditary) 11/2013 - 07/2005
3	Familial Multiple Coagulation Factor Deficiency I 09/2011 - 06/2003
3	Hypoxia (Hypoxemia) 07/2007 - 10/2005
2	Alzheimer Disease (Alzheimer's Disease) 01/2021 - 01/2014
2	Melanoma (Melanoma, Malignant) 01/2019 - 12/2009
2	Squamous Cell Carcinoma (Epidermoid Carcinoma) 01/2019 - 10/2006
2	Non-alcoholic Fatty Liver Disease 01/2018 - 01/2017
2	Anemia 01/2018 - 08/2009
2	Necrosis 10/2014 - 09/2013
2	Ischemia 05/2014 - 07/2007
2	Liver Diseases (Liver Disease) 01/2013 - 04/2011
2	Acute-Phase Reaction 10/2008 - 02/2006
1	Retinal Degeneration 11/2021
1	Retinitis Pigmentosa (Pigmentary Retinopathy) 11/2021
1	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 01/2021
1	Diabetes Mellitus 01/2021
1	Demyelinating Diseases (Demyelinating Disease) 01/2021
1	Parkinson Disease (Parkinson's Disease) 01/2021
1	Hepatomegaly 01/2021
1	Prediabetic State (Prediabetes) 11/2019
1	Alcoholism (Alcohol Abuse) 05/2019
1	Astrocytoma (Pilocytic Astrocytoma) 04/2019
1	Wounds and Injuries (Trauma) 01/2019
1	Iron Deficiencies 01/2018
1	Genetic Predisposition to Disease (Genetic Predisposition) 01/2018

Drug/Important Bio-Agent (IBA)

26	Proteins (Proteins, Gene)FDA Link 11/2021 - 04/2003
11	Factor VIII (Coagulation Factor VIII)IBA 07/2022 - 11/2002
10	Phosphotransferases (Kinase)IBA 03/2016 - 01/2002
8	Insulin (Novolin)FDA Link 01/2021 - 07/2005
6	ProinsulinIBA 11/2019 - 07/2005
6	Amino Acids FDA Link 03/2016 - 05/2003
6	Peptide Initiation Factors (Initiation Factor)IBA 01/2016 - 08/2005
5	AntioxidantsIBA 04/2019 - 07/2009
5	RNA (Ribonucleic Acid)IBA 01/2014 - 05/2003
4	Glucose (Dextrose)FDA LinkGeneric 01/2021 - 07/2007
4	Pharmaceutical PreparationsIBA 01/2019 - 04/2011
4	EnzymesIBA 01/2018 - 02/2009
4	LipidsIBA 01/2018 - 04/2011
4	Transcription Factors (Transcription Factor)IBA 01/2017 - 02/2006
4	Blood Coagulation Factors (Coagulation Factor)IBA 11/2013 - 11/2006
4	Factor V (Coagulation Factor V)IBA 09/2011 - 06/2003
3	Retinaldehyde (Retinal)IBA 11/2021 - 03/2013
3	Transcription Factor CHOPIBA 01/2016 - 06/2013
3	CalciumIBA 10/2014 - 12/2007
3	Glycoproteins (Glycoprotein)IBA 03/2014 - 02/2006
3	Protein Kinases (Protein Kinase)IBA 03/2013 - 12/2003
3	eIF-2 Kinase (eIF 2 Kinase)IBA 12/2009 - 04/2003
2	FructoseIBA 10/2020 - 01/2017
2	Reactive Oxygen Species (Oxygen Radicals)IBA 05/2019 - 12/2013
2	IronIBA 01/2018 - 08/2009
2	Inositol (Myoinositol)IBA 01/2018 - 03/2013
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 10/2016 - 07/2007
2	CytokinesIBA 10/2016 - 09/2013
2	Carrier Proteins (Binding Protein)IBA 01/2016 - 10/2008
2	Oxygen (Dioxygen)IBA 04/2015 - 07/2007
2	NitrogenIBA 04/2015 - 06/2004
2	UbiquitinIBA 05/2014 - 07/2007
2	Dextran SulfateIBA 04/2014 - 05/2013
2	Phosphoric Monoester Hydrolases (Phosphatases)IBA 09/2013 - 12/2009
2	Bortezomib (Velcade)FDA Link 04/2011 - 10/2006
2	Double-Stranded RNA (RNA, Double Stranded)IBA 04/2010 - 12/2003
2	DNA (Deoxyribonucleic Acid)IBA 10/2006 - 07/2004
2	Viral ProteinsIBA 02/2006 - 08/2005
2	NF-kappa B (NF-kB)IBA 02/2006 - 08/2003
1	Sirolimus (Rapamycin)FDA Link 07/2022
1	Interleukin-15 (Interleukin 15)IBA 07/2022
1	Rhodopsin (Visual Purple)IBA 11/2021
1	CalcineurinIBA 01/2021
1	SynucleinsIBA 01/2021
1	CholesterolIBA 10/2020
1	Serine C-PalmitoyltransferaseIBA 10/2020
1	DisulfidesIBA 11/2019
1	Disulfiram (Antabuse)FDA Link 05/2019
1	Nerve Growth Factor (NGF)IBA 04/2019
1	hesperetinIBA 01/2019
1	ResveratrolIBA 01/2019
1	Pyruvaldehyde (Methylglyoxal)IBA 01/2019
1	Hemoglobins (Hemoglobin)IBA 01/2018
1	Heme (Haem)IBA 01/2018
1	Mechanistic Target of Rapamycin Complex 1IBA 01/2018

Therapy/Procedure

8	Therapeutics 01/2019 - 07/2008
1	Drug Therapy (Chemotherapy) 01/2019
1	Cell- and Tissue-Based Therapy (Cell Therapy) 01/2019